Antihyperglycemic Effect of Syringaldehyde in Streptozotocin-Induced Diabetic Rats
Resource
Journal of Natural Products 75(8): 1465-1468
Journal
Journal of Natural Products
Journal Volume
75
Journal Issue
8
Pages
1465-1468
Date Issued
2012-08
Date
2012-08
Author(s)
Chia-Hsin Huang
Mei-Fen Chen
Hsien-Hui Chung
Juei-Tang Cheng
Abstract
The antihyperglycemic effect of syringaldehyde (1), purified from the stems of Hibiscus taiwanensis, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) showing type-1 like diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose-dependent manner in STZ-diabetic rats. An effective dose of 7.2 mg/kg of 1 attenuated significantly the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. A glucose uptake test showed that 1 exhibits an increase of glucose uptake activity in a concentration-related manner. Moreover, an effect by 1 was shown for insulin sensitivity in STZ-diabetic rats. The compound was found to increase insulin sensitivity in STZ-diabetic rats. These results suggest that syringaldehyde (1) can increase glucose utilization and insulin sensitivity to lower plasma glucose in diabetic rats.
Subjects
GLUCOSE-UPTAKE
HIBISCUS-TAIWANENSIS
PLASMA-GLUCOSE
CONSTITUENTS
ADIPOCYTES
STEMS
Publisher
ACS Publications
Type
journal article
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