莪朮的生藥學及抗增生成分研究
Journal
臺灣地區藥用植物資源之開發與利用學術研討會專刊
Part Of
農業試驗所特刊第48號
Pages
281-291
ISBN
957-00-5319-4
Date Issued
1995-04
Date
1995-04
Author(s)
侯鈺琪
陳忠川
邱年永
黃慧貞
李珮端
Abstract
莪朮是薑科薑黃屬植物Curcuma aeruginosa Roxb.之乾燥根莖，為常用之中藥。具有行氣破血，消積止痛之功效。用於治一切氣，消瘀血，心腹疼痛等症。近年來，臨床上用於治療早期的子宮頸癌及心血管疾病。以現代藥學觀點來看，其行氣通積聚之功，應為值得開發的抗腫瘤藥物來源。
本研究之生藥學部分，以我朮來源植物之一Curcuma aeruginosa Roxb.的主根莖，建立生藥組織圖，作為以後我朮類藥材基原植物鑑別研究之參考。而在化學活性成分之分析中，乃是以對人類的淋巴胚癌細胞（T-lymph-oid leukemia cell）之抗增生活性為指標，藥理活性試驗發現莪朮的乙酸乙酩層抽出物中之莪朮烯醇（curcumenol ) ，異莪朮烯醇（isocurcumenol), 莪朮環氧酮（zederone）及薑黃素（curcumin），對T-lymphoid leukemia cell 皆具抗增生活性，因此莪朮有進一步探究其抗癌活性之價值。
“O-Shuh” (莪朮) is the dired rhizome of Curcuma aeruginosa Roxb. (Zingiberaceae) It was widely used to remove blood stasis, promote circulation of qi and relieve pain in
clinical Chinese medicine. In recent years, it is also used to treat carcinoma of uterine cervix and angiocardiopathy.
The EtOAc fraction of “O-Shuh” was found to show antiproliferative activity on human T-lymphoid leukemia cells. Chemical investigation of this fraction was then conducted to result in the isolation of four known compounds: curcumenol isocurcumenol zederone and curcumin. Among the isolates, curcumenol was the richest constituent. Pharmacological study indicated that these four compounds all showed antiproliferative effect on human T-lym phoid leukemia cells.
Event(s)
臺灣地區藥用植物資源之開發與利用學術研討會
Proceeding of A Symposium on Development and Utilization of Resources of Medicinal Plants in Taiwan
Subjects
莪朮
組織鑑定
成分
Curcuma aeruginosa
anatomy
constituent
Publisher
農業試驗所
Type
conference paper
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