Studies on the production of some important secondary metabolites from medicinal plants by plant tissue cultures
Journal
Botanical Bulletin of Academia Sinica
Journal Volume
45
Journal Issue
1
Start Page
1
End Page
22
ISSN
0006-8063
Date Issued
2004-01
Author(s)
Mulabagal Vanisree
Chen-Yue Lee
Shu-Fung Lo
Satish Manohar Nalawade
Chien Yih Lin
Hsin-Sheng Tsay
Abstract
Plants are a tremendous source for the discovery of new products of medicinal value for drug development. Today several distinct chemicals derived from plants are important drugs currently used in one or more countries in the world. Many of the drugs sold today are simple synthetic modifications or copies of the naturally obtained substances. The evolving commercial importance of secondary metabolites has in recent years resulted in a great interest in secondary metabolism, particularly in the possibility of altering the production of bioactive plant metabolites by means of tissue culture technology. Plant cell culture technologies were introduced at the end of the 1960's as a possible toot for both studying and producing plant secondary metabolites. Different strategies, using an in vitro system, have been extensively studied to improve the production of plant chemicals. The focus of the present review is the application of tissue culture technology for the production of some important plant pharmaceuticals. Also, we describe the results of in vitro cultures and production of some important secondary metabolites obtained in our laboratory.
Subjects
biotransformations
cell suspension cultures
hairy root cultures
pharmaceuticals
secondary metabolites
SDGs
Publisher
Academia Sinica
Type
review