https://scholars.tari.gov.tw/handle/123456789/19392
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hou-I Lee | en_US |
dc.contributor.author | Jia-Hsin Guo | en_US |
dc.contributor.author | Chih-Chung Wu | en_US |
dc.contributor.author | Mao-Chang Ti | en_US |
dc.contributor.author | Kuang-Ping Lan | en_US |
dc.contributor.author | Chun-Yi Hu | en_US |
dc.contributor.author | Chih-Yong Lo | en_US |
dc.contributor.author | Chi-Ching Yang | en_US |
dc.contributor.author | Yaw-Feng Lin | en_US |
dc.contributor.author | Tzu-Ching Wang | en_US |
dc.date.accessioned | 2023-04-07T07:28:32Z | - |
dc.date.available | 2023-04-07T07:28:32Z | - |
dc.date.issued | 2011-04 | - |
dc.identifier.issn | 1388-0209 | - |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.3109/13880209.2010.517538 | - |
dc.identifier.uri | https://scholars.tari.gov.tw/handle/123456789/19392 | - |
dc.description.abstract | Objective: In the present study, we investigated the anti-inflammatory effect of C. taiwanianum T. Yamaza rhizome aqueous extract (CTAE). Materials and methods: The present study investigated the anti-inflammatory effect of CTAE using IL-1 beta beta-induced NRK-52E cells. Production of NO and PGE(2) by ELISA, the mRNA and protein expression of iNOS and COX-2, phosphorylation of I kappa kappa B alpha alpha, and activation of NF-kappa kappa B by RT-PCR and western blotting were determined. Results: The CTAE significantly (P < 0.05) inhibited NO and PGE(2) production (decreased by 46.1% and 51%, respectively), and also significantly (P < 0.05) attenuated protein and mRNA expression of iNOS and COX-2 (decreased by 90% and 55% for iNOS and by 72% and 74%% for COX-2, respectively) in IL-1 beta beta-induced NRK-52E cells, in a dose-dependent manner, without obvious cytotoxic effects. Furthermore, the CTAE suppressed the NF-kappa kappa B nuclear translocation, in terms of inhibition of I kappa kappa B alpha alpha phosphorylation. Discussion and conclusion: Our results provided evidence for its folkloric uses and suggest that the anti-inflammatory activities of CTAE may result from the inhibition of inflammatory mediators, such as NO and PGE(2), and an upstream suppression of a NF-kappa kappa B-dependent mechanism, might be involved. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Tylor & Francis Ltd. | en_US |
dc.relation.ispartof | Pharmaceutical Biology | en_US |
dc.subject | Cynanchum taiwanianum T. Yamaza | en_US |
dc.subject | anti-inflammatory effect | en_US |
dc.subject | cyclooxygenase-2 | en_US |
dc.subject | nitric oxide synthase | en_US |
dc.subject | nuclear factor-kappa B | en_US |
dc.title | Anti-inflammatory effects of Cynanchum taiwanianum rhizome aqueous extract in IL-1 beta beta-induced NRK-52E cells | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.3109/13880209.2010.517538 | - |
dc.identifier.pmid | 21388234 | - |
dc.identifier.isi | 000288758100016 | - |
dc.relation.journalvolume | 49 | en_US |
dc.relation.journalissue | 4 | en_US |
dc.relation.pages | 437-444 | en_US |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en_US | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
Appears in Collections: | SCI期刊 |
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