含酚類植物藥材對四氯化碳誘發肝障礙之保護作用

Abstract

22種含酣類台灣產植物之70％丙酮抽取物，由口服及腹腔注射投予，經四氯化碳(Carbon tetrachioride)誘發急性肝障礙之ICR鼷鼠，結果口服各藥材以太魯閣樑(Quercus tarokoensis Hay)、稜果蒲桃(Eugenia uniflora Linn.)、大頭茶(Cordonia uxilloris (Roxb.) Hert. et News.)、能高山茶((Cammellia no k-oensis Hay.)、香港饅頭果(Clochidion hongkongense Moell-Arg.)；而腹腔注射則以垢果山茶(Camellia furfuracae (Merr.) Cohen- Stuart)、稜果蒲桃(Eugonia uniflora Linn.)、大頭茶(Gordonia oxillaris (Roxb.) Hort. et News.)、太魯閣礫(Quercus tarokoensis Hay.)具有有意義之保肝作用，因有待逐一分離抽取其保肝活性之成分，以開發新的肝炎治療藥物。 22 kinds of polyphenol containing plants were collected form Taiwan. Their 70% acctone extracts were oral administration and peritoneal inje-ction to the carbon tetrachioride induced livcr damage ICR mice. The serum GOT and GPT were regardod as protectIve index. Quercus tarokoensis, Eugenia uniflora, Godonia axillonis axilloris, Camellia nokoensis and Glochidion hongkougense were oxhibited remarkable anti hepatotoxic activity by o. p. administrtion Otherwise, Camellia furluracae, Eugenia unufolora, Godonia axillaris and Quercus tarokoensis also exhibited remarkable antihepatotoxic activity by i.p. *correnspondent