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Please use this identifier to cite or link to this item: https://scholars.tari.gov.tw/handle/123456789/4189
Title: Comparing the Protection Imparted by Different Fraction Extracts of Garlic (Allium sativum L.) against Der p-Induced Allergic Airway Inflammation in Mice
Authors: Chia-Chen Hsieh
Keng-Fan Liu
Pei-Chun Liu
Yaw-Tsan Ho
Wei-Sung Li 
Wen-Huang Peng
Jen-Chieh Tsai
Keywords: garlic;asthma;Der p;anti-inflammatory;Th1;Th2
Issue Date: Oct-2019
Publisher: Switzerland : MDPI
Journal Volume: 20
Journal Issue: 19
Start page/Pages: 4879
Source: International Journal of Molecular Sciences 
Abstract: 
Garlic (Allium sativum L.) has been used extensively as a food ingredient and medicinally, but the effect on asthmatic airway inflammation has not been studied in detail. We accordingly explored the protective effects exerted by various garlic fraction extracts against airway inflammation with Dermatophagoides pteronyssinus (Der p)-induced allergic asthma in vivo and in vitro. Garlic extraction was realized using n-hexane, dichloromethane, ethylacetate, n-butanol, and water in sequence to obtain different fraction extracts. Mice were orally administered different fractions (80 mg/kg) daily for four weeks. The histological results showed that the water fraction could ameliorate lung-based goblet cell hyperplasia, inflammatory cell infiltration, and mucus hypersecretion. The water fraction extracts decreased IgE and IgG1, and they decreased inflammatory cells as quantified in bronchoalveolar lavage fluid (BALF); however, they increased IgG2a in serum. Moreover, the water fraction extracts increased IFN-gamma and IL-12 (both constituting Th1 cytokines) in BALF, but they reduced IL-13, -4, and -5 (all constituting Th2 cytokines), and also inhibited the expression of IL-1 beta, IL-6, and TNF-alpha. The water fraction also inhibited the PI3K/Akt/NF-kappa B signal pathways in A549 cells. These findings suggest that water fraction extracts of garlic have a clear anti-inflammatory effect on Der p-induced allergic asthma.
URI: https://scholars.tari.gov.tw/handle/123456789/4189
https://www.mdpi.com/1422-0067/20/19/4879
ISSN: 1422-0067
DOI: 10.3390/ijms20194879
Appears in Collections:SCI期刊

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