Comparative Analysis of Xanthine Oxidase and Lipase Inhibition by Extracts from Different Mesona chinensis Cultivars
Other Title
不同仙草品種萃取物對黃嘌呤氧化酶與脂肪酶抑制活性的比較分析
Journal
台灣農業研究
Journal Volume
74
Journal Issue
3
Start Page
291
End Page
301
ISSN
2790-086X
Date Issued
2025-09-07
Author(s)
Abstract
This study investigated the differential inhibitory activities of five major Taiwanese Mesona chinensis Benth. cultivars (‘Taoyuan No. 1’, ‘Taoyuan No. 2’, ‘Taoyuan No. 3’, ‘TARI No. 1’, and ‘Shuishang’) against xanthine oxidase and lipase and explored their correlations with rosmarinic acid and caffeic acid content. The experimental results revealed significant inter-cultivar variations in the inhibitory activities against both enzymes among the different M. chinensis cultivars. ‘TARI No. 1’ exhibited the strongest xanthine oxidase inhibition (68.5%), while ‘Taoyuan No. 2’ (59.6%) and ‘Taoyuan No. 3’ (59.2%) showed greater lipase inhibitory effects. A high positive correlation (r = 0.735) was observed between the rosmarinic acid content of M. chinensis extracts and xanthine oxi-dase inhibition, suggesting rosmarinic acid as a potential indicator for this activity. Conversely, caffeic acid content showed a negative correlation (r = -0.807) with lipase inhibition, implying that other constituents in M. chinensis may contribute to lipase inhibitory activity. Notably, ‘Taoyuan No. 3’, a hybrid of ‘Taoyuan No. 1’ and ‘Taoyuan No. 2’, displayed enzyme inhibitory activity similar to that of ‘Taoyuan No. 2’, suggesting a potentially similar genetic expression pattern for the biosynthetic path-ways of active components for enzyme inhibitory activity. These findings provide a basis for selecting specific M. chinensis cultivars for targeted metabolic regulation applications.
本研究旨在探討臺灣 5 種主要仙草 (Mesona chinensis Benth.) 品種 (「桃園 1 號」、「桃園 2 號」、「桃園 3 號」、「農試 1 號」及「水上種」) 對黃嘌呤氧化酶 (xanthine oxidase) 與脂肪酶 (lipase) 的抑制活性差異，並探究其與迷迭香酸 (rosmarinic acid) 與咖啡酸 (caffeic acid) 含量的相關性。實驗結果顯示，不同仙草品種間對 2種酵素的抑制活性存在顯著的品種間差異。其中，「農試 1 號」表現出最強的黃嘌呤氧化酶抑制活性 (68.5%)，而「桃園 2 號」 (59.6%) 與「桃園 3 號」 (59.2%) 則對脂肪酶展現較佳的抑制效果。仙草萃取物中迷迭香酸含量與黃嘌呤氧化酶抑制率呈現高度正相關 (r = 0.735)，顯示迷迭香酸可能適合作為黃嘌呤氧化酶抑制活性的指標成分。相反地，咖啡酸含量與脂肪酶抑制活性呈現負相關 (r = -0.807)，暗示仙草中其他成分可能影響脂肪酶抑制活性。值得注意的是，作為「桃園 1 號」與「桃園 2 號」雜交後代的「桃園 3 號」，其酵素抑制活性與「桃園 2 號」相似，這暗示「桃園 3 號」酵素抑制活性成分的生物合成途徑可能展現與「桃園 2 號」更為接近的遺傳表達模式。本研究結果為未來選擇合適的仙草品種應用於目標代謝調節提供了依據。
Subjects
Mesona chinensis
Xanthine oxidase
Lipase
Enzyme inhibition activity
Constituent analysis
仙草
黃嘌呤氧化酶
脂肪酶
酶抑制活性
成分分析
Publisher
農業部農業試驗所
Type
journal article
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