Garlic-derived allyl sulfides attenuate house dust mite-induced allergic airway inflammation associated with reduced PI3K/NF-κB signaling
Journal
FRONTIERS IN PHARMACOLOGY
Journal Volume
17
Start Page
1906382
ISSN
1663-9812
Date Issued
2026-09
Author(s)
Hsu-Chung Liu
Keng-Fan Liu
Mann-Jen Hour
Chia-Chen Hsieh
農業部農業試驗所
Hong-Zin Lee
Jen-Chieh Tsai
Abstract
Background: Allergic asthma, characterized by chronic airway inflammation, is often triggered by Dermatophagoides pteronyssinus (Der p). Garlic-derived allyl sulfides, including diallyl trisulfide (DATS), diallyl disulfide (DADS), and S-allyl-L-cysteine (SAC), possess anti-inflammatory properties, yet their effects on allergic asthma remain unclear. This study aimed to investigate the protective effects of these compounds on Der p-induced allergic asthma and to elucidate their underlying mechanisms in vivo and in vitro.
Subjects
asthma
Der p
house dust mite
immune modulation
PI3K/NF-kappa B
S-allyl-l-cysteine
SDGs
Publisher
FRONTIERS MEDIA SA
Type
journal article