在攝取高膽固醇下不同穀類為醣類來源對大白鼠脂質代謝之影響

Abstract

本研究之目的是探討以在攝取高膽固醇下不同穀類為醣類來源對大白鼠體內脂質代謝之影響，將Wistar 品系之雄鼠隨機分成六組，分別餵予添加l ％膽固醇之玉米澱粉、秈米、粳米、糯米、小麥及燕麥等六種高膽固醇飼料，實驗進行四週後，分析血清三酸甘油醋、總膽固醇、高密度及低密度脂蛋白膽固醇，肝臟三酸甘油醋及總膽固醇，以及糞便中性固醇與總膽酸。結果顯示在高膽固醇情況下，與玉米澱粉組（對照組）比較，秈米組與粳米組有較低之血脂質(P < 0 . 05 )。所有實驗組均有較對照組低之肝脂質及糞便中性固醇濃度，但以燕麥組最低，三種米類次之，小麥較高(P < 0 . 05 ) 。糞便總膽酸則為秈米、小麥、燕麥組較對照組高(P < 0 . 05 )。所有實驗組之肝臟總膽固醇濃度均較對照組低“糞便中性固醇排出量各實驗組均較對照組高(P < 0 . 05 ) ；總膽酸排出量則是糯米、小麥及燕麥組較對照組高(P < 0 . 05 )。由此結果可知在降低血清脂質方面以秈米及粳米效果最好。降低肝臟脂質堆積之效果在攝取高膽固醇時以燕麥效果最佳，米類次之，小麥再次之。 This study was to investigate the effects of various cereals on lipid metabolism in rats. Thirty -six adult male Wistar rats were randomly divided into six groups, all of which were fed diets containing 1% cholesterol. The six groups included: Corn starch group (+C), Indica rice group (-fIR), Japonica rice group (+JR), Waxy rice group (+WR), Wheat group (+W) and Oat group(+O). Rats were sacrificed after four-week feeding, and artery blood, liver and feces were collected. Analytical items included serum triglyceride, total cholesterol, HDL- cholesterol, LDLcholesterol, liver triglyceride and cholesterol, fecal neutral steroids and bile acids. The results showed that +IR and +JR had lower serum lipid levels than +C (p<O.05). All groups had lower liver lipid and fecal neutral steroid concentration than +C: +0 was lower than others, and +IR, +JR, +WR were lower than +W (p<O.O5). +IR, +W, and +0 had higher fecal bile acid content than +C (p<O.O5). All groups had lower liver cholesterol concentration, (p<O.O5). All groups had lower fecal neutral steroids content than +C (p<O.O5).