The pharmarcological studies of Actinidiae chinensis Planch.var.setosa on the cetral nervous system
|Keywords:||臺灣地區藥用植物資源之開發與利用學術研討會專刊;Actinida chinensis (A.C.);locomotor activity;water extract;serotonergic;GABAergic;Proceeding of A Symposium on Development and Utilization of Resources of Medicinal Plants in Taiwan||Issue Date:||Apr-1995||Publisher:||台中：農業試驗所||Start page/Pages:||231-257||Source:||臺灣地區藥用植物資源之開發與利用學術研討會專刊:||Abstract:||
The stem of Actinida chinensis Planch.var.setosa(abbreviated as A.C.)was used for insomnia by Chinese traditional physicians. In this study, we used phytochemical and behavioral pharmacological methods to search the sedative compounds and to investigate their effects on the central nervous system.
All of the five extracts of A.C. had low toxicity, prolonged the sleeping time induced by hexobarbital in mice and reduced the locomotor activity in rats. The water extract had the strongest sedative effect than the other extracts. None of the five extracts showed muscle relaxant effect. Ethanol-n-butanol-, and water-extracts reduced tonic convulsion time induced by pentylenetetrazol. Both of ethanol extract and water extract inhibited the swelling volume of rat hind-paw induced by carrageenin, hot plate-induced pain response and acetic acid-induced writhing response. The water extract enhanced analgesic effect produced by baclofen. It potentiated the hypomotility produced by 5-HTP and baclofen. It also reduced the hypermotility produced by PCPA.
From these results, it was found that A.C.extracts had analgesic, sedative, anticonvulsive and anti-inflammatory effects. Ths water extract had the best analgesic and sedative effect. It might be involved in the increase in the serotonergic and GABAergic activities.
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