|Title:||Optimization of cultivation conditions for fungichromin production from Streptomyces padanus PMS-702||Authors:||Jiun-Yan Wu
|Keywords:||Streptomyces padanus PMS-702;Fungichromin;Response surface methodology;Polyene macrolide antibiotic;Optimization||Issue Date:||Jan-2008||Publisher:||Elsevier||Journal Volume:||39||Journal Issue:||1||Start page/Pages:||67-73||Source:||Journal of the Chinese Institute of Chemical Engineers||Abstract:||
A novel strain, Streptomyces padanus PMS-702, was employed to produce fungichromin (FC, a polyene macrolide antibiotic) in a shake flask cultivation. In comparing the effects of various carbon and nitrogen sources on PMS-702 cultivation, it was found that glucose and soybean meal medium yielded the highest FC within 2 days. Factors such as medium composition, cultivation temperatures, and initial pH were optimized for FC production with response surface methodology (RSM). The optimal cultural condition obtained is as follows: glucose 11.2 g/L, soybean meal 11.2 g/L, CaCO3 0.46 g/L, temperature 31.7 °C, and an initial pH 5.5. Under these conditions, FC production reached 112 mg/L, about an increase of 2.86 times, as compared to results under basic conditions.
|Appears in Collections:||SCI期刊|
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