https://scholars.tari.gov.tw/handle/123456789/3935
Title: | Optimization of cultivation conditions for fungichromin production from Streptomyces padanus PMS-702 | Authors: | Jiun-Yan Wu Jenn-Wen Huang Hsin-Der Shih Wei-Chen Lin Yung-Chuan Liu |
Keywords: | Streptomyces padanus PMS-702;Fungichromin;Response surface methodology;Polyene macrolide antibiotic;Optimization | Issue Date: | Jan-2008 | Publisher: | Elsevier | Journal Volume: | 39 | Journal Issue: | 1 | Start page/Pages: | 67-73 | Source: | Journal of the Chinese Institute of Chemical Engineers | Abstract: | A novel strain, Streptomyces padanus PMS-702, was employed to produce fungichromin (FC, a polyene macrolide antibiotic) in a shake flask cultivation. In comparing the effects of various carbon and nitrogen sources on PMS-702 cultivation, it was found that glucose and soybean meal medium yielded the highest FC within 2 days. Factors such as medium composition, cultivation temperatures, and initial pH were optimized for FC production with response surface methodology (RSM). The optimal cultural condition obtained is as follows: glucose 11.2 g/L, soybean meal 11.2 g/L, CaCO3 0.46 g/L, temperature 31.7 °C, and an initial pH 5.5. Under these conditions, FC production reached 112 mg/L, about an increase of 2.86 times, as compared to results under basic conditions. |
URI: | https://scholars.tari.gov.tw/handle/123456789/3935 | ISSN: | 1876-1070 | DOI: | 10.1016/j.jcice.2007.11.006 |
Appears in Collections: | SCI期刊 |
File | Description | Size | Format | |
---|---|---|---|---|
index.html | 22 kB | HTML | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.