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Please use this identifier to cite or link to this item: https://scholars.tari.gov.tw/handle/123456789/3935
Title: Optimization of cultivation conditions for fungichromin production from Streptomyces padanus PMS-702
Authors: Jiun-Yan Wu
Jenn-Wen Huang
Hsin-Der Shih 
Wei-Chen Lin
Yung-Chuan Liu
Keywords: Streptomyces padanus PMS-702;Fungichromin;Response surface methodology;Polyene macrolide antibiotic;Optimization
Issue Date: Jan-2008
Publisher: Elsevier
Journal Volume: 39
Journal Issue: 1
Start page/Pages: 67-73
Source: Journal of the Chinese Institute of Chemical Engineers 
Abstract: 
A novel strain, Streptomyces padanus PMS-702, was employed to produce fungichromin (FC, a polyene macrolide antibiotic) in a shake flask cultivation. In comparing the effects of various carbon and nitrogen sources on PMS-702 cultivation, it was found that glucose and soybean meal medium yielded the highest FC within 2 days. Factors such as medium composition, cultivation temperatures, and initial pH were optimized for FC production with response surface methodology (RSM). The optimal cultural condition obtained is as follows: glucose 11.2 g/L, soybean meal 11.2 g/L, CaCO3 0.46 g/L, temperature 31.7 °C, and an initial pH 5.5. Under these conditions, FC production reached 112 mg/L, about an increase of 2.86 times, as compared to results under basic conditions.
URI: https://scholars.tari.gov.tw/handle/123456789/3935
ISSN: 1876-1070
DOI: 10.1016/j.jcice.2007.11.006
Appears in Collections:SCI期刊

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